Molecular Omics and Toxicology Research Group

Welcome to Molecular Omics and Toxicology Research Group!
Our research group is dedicated to advancing the understanding of complex biological systems through the integration of molecular omics and toxicology. Our focus lies in two critical areas: Systems Biomedicine and Cancer Omics, and Mechanistic and Developmental Toxicology.

About Us

Mission Statement:
Our mission is to unravel the intricate biological mechanisms underlying cancer and toxicological responses to environmental pollutants. We aim to contribute to the development of innovative therapeutic strategies and safer environmental practices through comprehensive and integrative research approaches.

Research Focus:

Systems Biomedicine and CancerOmics

Overview: Our research in this area emphasizes cancer genetics, informatics, and drug repositioning strategies. We utilize a systems biology perspective and multi-omics approach to explore the genetic and molecular foundations of cancer, aiming to identify new therapeutic targets and enhance existing treatments through innovative drug repurposing.

Key Areas:

• • • Cancer Genetics
    • Cancer Informatics
    • Drug Repositioning
    • Multi-Omics Approaches
    • Systems Toxicology

 

Mechanistic and Developmental Toxicology

Overview: This research focuses on the detrimental effects of various pollutants, including plasticizers, PFAS, pesticides, nano-/micro-plastics, drugs, and new-generation compounds. We examine these substances at both acute and chronic exposure levels using a multi-omics approach that includes transcriptomics, metabolomics, and proteomics.

Key Areas:

• • • Environmental Pollutants
    • Acute and Chronic Exposure
    • Transcriptomics, Metabolomics, Proteomics
    • Toxicological Endpoints (e.g., mortality, teratogenic effects)

 

Research Models and Techniques:

• Zebrafish: Utilized to study developmental processes and toxicological impacts.
• Daphnia magna: Used for assessing aquatic toxicity and environmental impact.
• Cell Cultures: Employed for detailed molecular and cellular analyses.
• Probiotic cells:  Used for assessing drug and chemical effects.

 

Recent Publications:

• Turanli, B., Gulfidan, G., Aydogan, O. O., Kula, C., Selvaraj, G., & Arga, K. Y. (2024). Genome-scale metabolic models in translational medicine: the current status and potential of machine learning in improving the effectiveness of the models. Molecular Omics, 20(4), 234-247.
• Budak, B., Tükel, E. Y., Turanlı, B., & Kiraz, Y. (2024). Integrated systems biology analysis of acute lymphoblastic leukemia: unveiling molecular signatures and drug repurposing opportunities. Annals of Hematology, 1-14.
• Bereketoglu, C., Häggblom, I., Turanlı, B., & Pradhan, A. (2024). Comparative analysis of diisononyl phthalate and di (isononyl) cyclohexane‐1, 2 dicarboxylate plasticizers in regulation of lipid metabolism in 3T3‐L1 cells. Environmental Toxicology, 39(3), 1245-1257.
• Kim, Y., Bereketoglu, C., Sercinoglu, O., & Pradhan, A. (2024). In Vitro, In Vivo, and In Silico Analysis of Pyraclostrobin and Cyprodinil and Their Mixture Reveal New Targets and Signaling Mechanisms. Chemical Research in Toxicology, 37(3), 497-512.

 

Our Team

Group Leaders:

• Assoc. Prof. Dr. Beste Turanlı
• Assoc. Prof. Dr. Ceyhun Bereketoğlu
  
  

PhD Students:

• Mustafa Yavuz
• Özge Önlütürk Aydoğan
  
  

MSc Students:

• Sena Özyiğit
• Recep Anıl Kaya
• Elif Serap Gürler
  
  

BSc Students:

• Yusuf Talha Başaran
• Tunahan Tekerek
• Aytaç Dursun Öksüzoğlu
• Nezahat Ertürk
  
  

Collaborations and Funding

Collaborates:

• Prof. Mehmet Lütfi Yola, Hasan Kalyoncu University
• Assoc. Prof. Ajay Pradhan, Örebro University
• Prof. Adil Mardinoglu, KTH
• Prof. Raghu Sinha, Penn State University
• Assist. Prof. Yağmur Kiraz, Izmir Economy University
• Assist. Prof. Saliha Ece Acuner, Istanbul Medeniyet University

 

Funding Sources:

• Marmara University ADEP
• TÜBİTAK
• TÜSEB

 

 

News and Events

Upcoming Events:

To be announced

Recent News:

To be announced

 

Contact Us

Address:
Marmara University, Faculty of Engineering, Department of Bioengineering, M2 B03, Aydınevler, Maltepe/İstanbul, Türkiye

Email: beste.turanli@marmara.edu.tr

            ceyhun.bereketoglu@marmara.edu.tr

 

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